Cydem VT System

Automated Cell Culture System

The Cydem VT Automated Cell Culture System combines multiple trusted Beckman Coulter Life Sciences technologies into one advanced platform that empowers lab managers with a far more effective, higher-throughput method for top clone screening in Cell Line Development—offering increased confidence that promising clones don’t get overlooked in the process of consistently selecting the best. 

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Features of the Cydem VT Automated Cell Culture System

Combining multiple Beckman Coulter technologies into a single, standalone platform, the Cydem VT Automated Cell Culture System opens up a whole new world to hard-working lab managers and scientists, who strive daily for success in the high-pressure world of Cell Line Development. Gain more understanding from more clones from one single experiment.

Integrated Bioreactor Module

  • Cultivate 96 clones in parallel in 24-deep well bioreactor plates
  • Unique gassing chip for well-individual gassing control
  • Maintain optimal pH and DO levels in your cultivations
     

Integrated Cell Count and Viability Module

  • Regular updates of cell count and viability throughout your entire experiment
  • Accurate and precise measurements with low sample volume
  • Utilizes our well-known Vi-CELL BLU Analyzer technology
     

Integrated Titer Module

  • Regular antibody titer measurements

  • Learn more about the productivity of your clones

  • Make informed decisions about your clone selection

  • Small sample volume

Introducing the Cydem VT Automated Clone Screening System

 


High Throughput

96 x 5 mL parallel microbioreactors

Optimized Selection Confidence

pH-controlled, fed-batch conditions with individual gassing regulation (CO2 & dissolved oxygen) in each parallel microbioreactor

Early Insights

Regular on-deck cell count, viability and titer measurements throughout the entire cultivation

Full Automation

Less manual work and human error;
reduced risk of contamination

3-Day Walk-Away Automated Operation with Auto-Normalization of Cell Density

  • Fully integrated solution with on-deck cell count, cell viability, mAbs titer, pH, and DO measurement
  • 3-day walk-away automated operation
  • Automated seeding of cell cultures
  • Schedule builder for analytical measurements, feeding strategy, and pH control
  • Centralized data on one instrument with the ability to easily export in .csv format
  • Single point of contact for sales, service, and technical support for the entire system, consumables, and reagents

Clone screening of 96 clones over 14 days. Viable cell density and mAbs titer displayed over the course of the experiment. For a better overview, 10 clones with different growth and productivity performances were selected.

Resources

Introducing the Cydem VT Automated Cell Culture System: A high-throughput platform for fast and reliable clone screening experiments

 

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Cydem VT Automated Clone Screening System - Generating an Antibody Standard Curve

 

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Efficient clone screening with increased process control and integrated cell health and titer measurements with the Cydem VT Automated Clone Screening System

 

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Cultivation of Mammalian Cells
in the Cydem VT System Bioreactor Module

 

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Technical Instrument Parameters

 

Specifications Description
Combined size (instrument + workstation cart)I • Width: 183 cm (72 in.)
• Depth: 82 cm (32 in.)
• Height: 228 cm (89.5 in.) with door closed
• Height: 233 cm (91.5 in.) with door open
Instrument sizeI • Width: 170 cm (67 in.)
• Depth: 82 cm (32 in.)
• Height: 142 cm (56 in.) with door closed
• Height: 147 cm (58 in.) with door open 
Workstation cart size2 • Width: 183 cm (72 in.)
• Depth: 82 cm (32 in.)
• Height: 85 cm (33.5 in.)
Weight • Combined weight: 567 kg (1250 lbs)
• Instrument only: 340 kg (750 lbs)
• Workstation cart only: 227 kg (500 lbs)

 

I Including HEPA filter
2 Workstation cart is always included in the Cydem VT system

 

 

dimensions cydem vt


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Frequently Asked Questions

The Cydem VT system supports the shaken cultivation of Chinese Hamster Ovary (CHO) cells.

The Cydem VT system allows for a pH-controlled fed-batch cultivation for 96 clones, with well-specific gassing control for pH (CO2) and dissolved oxygen (DO) control. The liquid handler can add liquid base for additional pH control.

The Cydem VT Automated Cell Culture System can screen up to 96 clones in parallel shaken 5 mL microtiter plate format.

The Cydem VT system uses Valita Titer Assay technology and can quantify all Fc-containing molecules (e.g., IgG-based antibodies IgG 1, 2, 3, and 4 subclasses, standard, bispecific, fusion protein formats, etc.).

You can find all technical documentation here.

The working volume is in a range of 3-5 mL.

The system provides regular on-deck measurements of pH and dissolved oxygen (DO) values, monoclonal antibody (mAb) titer, and cell count and viability.

 

*Product in development. Performance characteristics have not been validated. For Research Use Only. Not for use in diagnostic procedures.